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KMID : 1140220160210010048
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대한암예방학회지
2016 Volume.21 No. 1 p.48 ~ p.54
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Anti-inflammatory and Anti-tumorigenic Effects of A?ai Berry in Helicobacter felis-infected mice
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Lee Ju-Yup
Kim Na-young
Choi Yoon-Jeong
Nam Ryoung-Hee
Lee Seon-min
Ham Min-Hee
Suh Ji-Hyung
Choi Yoon-Jin
Lee Hye-Seung
Lee Dong-Ho
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Abstract
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Background:The aim of this study was to evaluate the anti-inflammatory and anti-tumorigenic effect of a?ai berry after chronic Helicobacter felis colonization in the stomachs of C57BL/6 mice.
Methods:A total of 57 four-week-old female C57BL/6 mice (18 control mice and 39 experimental mice) were used. The mice were administered orogastrically with vehicle only or vehicle containing H. felis, 5 times every other day. After inoculation of H. felis, mice were fed either a standard or an a?ai-containing diet and then sacrificed at 4, 24, and 52 weeks. The infection status and degree of inflammation were determined by culture and histopathology. The level of gastric mucosal myeloperoxidase (MPO), TNF-α, and interleukin-1β (IL-1β) were measured by ELISA.
Results:At 24 weeks after inoculation, mucosal atrophy and mucous metaplasia appeared in all infected mice. At 52 weeks after inoculation, dysplastic change was noted in 10%, 25%, and 50% of mice in the H. felis-control, H. felis-a?ai 5%, and H. felis-a?ai 10% groups, respectively. The neutrophil, monocyte, atrophy, and metaplasia grades of infected mice showed no significant difference among the H. felis-infected groups. H. felis-infected mice fed with a?ai berry showed no significant difference compared with H. felis-infected control mice in gastric mucosal MPO, TNF-α, and IL-1β levels.
Conclusions:H. felis that colonized the stomachs of C57BL/6 mice provoked inflammation, and induced mucosal atrophy, metaplasia, and dysplasia. However, a?ai berry did not effectively prohibit the gastric carcinogenesis which was induced by chronic H. felis infection.
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KEYWORD
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Acai (Euterpe oleracea), Stomach, Helicobacter felis, Inflammation
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